Chemist Warehouse South Melbourne is located at 310 Clarendon Street, one of the chain's branches serving the inner south side of Melbourne. Like other Chemist Warehouse stores, it follows a large-format retail model, with wide aisles stocking discounted prescription and over-the-counter medicines, vitamins, cosmetics, skincare and household health products alongside the pharmacy counter itself. A registered pharmacist is available on site for prescription dispensing, medication advice and consultations, and no appointment is needed to be served at the pharmacy counter. The store trades long hours on weekdays, opening from 8am until 9pm Monday to Friday, with slightly shorter hours on weekends, which makes it a practical option for people picking up prescriptions or health essentials outside typical business hours. This branch suits South Melbourne locals doing a broader shop for toiletries, vitamins or over-the-counter remedies alongside a prescription, as well as anyone after competitively priced health and beauty items. Its Clarendon Street position puts it within easy reach of the surrounding residential streets and nearby Albert Park, and its scale means it typically carries a wider range of stock than a smaller independent pharmacy.